Thursday, September 10, 2009



Acrodysostosis is an extremely rare disorder that is present at birth (congenital). People with this condition have problems in the bones of the hands, feet, and nose, and mental retardation.


Most patients with acrodysostosis have no family history of the disease. However, sometimes the condition is passed down from parent to child. Parents with the condition have a 1 in 2 chance of passing the disorder to their children.

There is a slightly greater risk with fathers who are older.


  • Frequent middle ear infections
  • Growth problems, short arms and legs
  • Hearing problems
  • Mental deficiency
  • Unusual looking face

Exams and Tests

A physical exam confirms this disorder.

Findings may include:

  • Advanced bone age
  • Bone deformities in hands and feet
  • Delays in growth
  • Problems with the skin, genitals, teeth, and skeleton
  • Short arms and legs with small hands and feet
  • Short head, measured front to back (brachycephaly)
  • Short height
  • Small, upturned broad nose with flat bridge
  • Unusual features of the face (short nose, open mouth, jaw that sticks out)
  • Unusual head
  • Wide-spaced eyes (hypertelorism), sometimes with extra skin fold at corner of eye

In the first months of life, x-rays may show spotty calcium deposits, called stippling, in bones (especially the nose). Infants may also have:

  • Abnormally short fingers and toes (brachydactyly)
  • Early growth of bones in the hands and feet
  • Short bones
  • Shortening of the forearm bones near the wrist


Treatment depends on the physical and mental problems that occur.

Orthopedic care, early intervention, and special education are recommended.

Outlook (Prognosis)

Problems depend on the degree of skeletal involvement and mental retardation. In general, patients do relatively well.

Possible Complications

When to Contact a Medical Professional

Call your health care provider if your child seems to be growing or developing slowly or abnormally, or if you notice physical abnormalities in your infant.


Consider genetic counseling to help with diagnosis, testing, and identifying risk.


Cobb's angle, a measurement used for evaluation of curves in scoliosis on an AP radiographic projection of the spine . When assessing a curve the apical vertebra is first identified; this is the most likely displaced and rotated vertebra with the least tilted end plate. The end/transitional vertebra are then identified through the curve above and below. The end vertebra are the most superior and inferior vertebra which are least displaced and rotated and have the maximally tilted end plate. A line is drawn along the superior end plate of the superior end vertebra and a second line drawn along the inferior end plate of the inferior end vertebra. If the end plates are indistinct the line may be drawn through the pedicles. The angle between these two lines (or lines drawn perpendicular to them) is measured as the Cobb angle. In S-shaped scoliosis where there are two contiguous curves the lower end vertebra of the upper curve will represent the upper end vertebra of the lower curve. Because the Cobb angle reflects curvature only in a single plane and fails to account for vertebral rotation it may not accurately demonstrate the severity of three dimensional spinal deformity. As a general rule a Cobb angle of 10 is regarded as a minimum angulation to define scoliosis.

Wednesday, September 9, 2009

Proud of Neuro-Pathology

Dr Anshu Gupta
Associate Professor
MBBS , MD (Pathology)
O.I/C , Emergency Lab
Institute of Human Behaviour and Allied Sciences,Delhi

This article describe about the life achievement of that person who is completely dedicated for the patient care services in neuro-pathology field. A person not only hard working and sincere but helpful to the needy patients and friendly ,supportive and co-operative with her collegues . This inspired the other persons too ,who connected to the patient care services directly or indirectly.

Dr Anshu Gupta's profile:-

Dr Anshu Gupta graduated from Pt.BD Sharma Post Graduate Institute of Medical Sciences,Rohtak,India.
She did her MD in Pathology from the same college. Dr Anshu Gupta joined Pt. B.D Sharma Post Graduate Institute of Medical Sciences as a Assistant Professor and presently giving her services as a Associate Professor and Officer In Charge of Emergency Laboratory in the Department of Neuro-pathology at Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi .Her research papers and articles published in national and international journals like Indian Journal of Pathology and Microbiology , Springer Journal , Indian Journal of Urology ,Wiley InterScience etc

Important Neuro-Pathology Facilities available at IHBAS:

This Institute is one of the reputed Institute of Northern India for the treatment of different types of Mental disorders e.g Epilepsy and its different types,Dementia,Alzhiemers,Cerebal Palsy,Depression ,Movement Disorders,Fits,Tremors , Brain Tumors,Mental Retardation etc. IHBAS has a facility of different Neuro-Patholoical Biological instruments like optical Microscope etc.All instruments are of international Standards for study the human tumors using Histopathology and Cytology procedures.Urine and Blood Characterization performed in Neuro-Pathology Laboratory from well trained Technicians and Consultants on a modern instruments. Beside this IHBAS has a facility of high power 3T-MRI (3 tesla=30,000 guass) which can provide the better resolution of the soft tissues than normal MRI.It is available only at few parts of Delhi.

Some of her famous published articles and research papers in leading journals:-

Giant appendicular schwannoma in a child in Indian Journal Pathology Microbiology - 52(2), april-june 2009

A case report on Acute pancreatitis: a rare cause of acute abdomen in pregnancy Volume 279, Number 4 / April, 2009 published in Springer Journal: Archives of Gynecology and Obstetrics

Obstructive anuria due to blood clot : Volume 278, Number 4 / October, 2008 published in Springer Journal : Archives of Gynecology and Obstetrics

A Case Report on Testicular granulosa cell tumor, adult type :Year : 2008 | Volume : 51 | Issue : 3 |Page : 405-406 published in 2008 Indian Journal of Pathology and Microbiology

Adrenal angiomyolipoma: A rare entity Indian Journal of Urology in July-Sept 2007

A case report on Ovarian actinomycosis in absence of intrauterine contraceptive device: an unusual presentation published in Wiley Interscience in 2002:

For Queries Regarding Neuro-Pathology Imaging ,feel free to Contact from the concern Person:-

Dr Anshu Gupta
Associate Professor
MBBS , MD (Pathology)
O.I/C , Emergency Lab
IHBAS,,Delhi or in Academic Block in Room No 212

!!! Mental Illness is Treatable
!!! Contact your Physician if any side effect arise from the Medication.